Metformin primarily reduces hepatic glucose production and improves peripheral insulin sensitivity, while tirzepatide enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety
But right now, unfortunately, it is unsustainable. The states biggest private insurer, Blue Cross Blue Shield of Massachusetts, also axed coverage of GLP-1 drugs for weight loss this year because the costs were driving up premiums for all members
Wang L, Xu R, Kaelber DC, Berger NA
Surg Obes Relat Dis Off J Am Soc Bariatr Surg
However, there are fewer studies on the effect of DPP4 inhibitors on hepatic oxidative stress and liver disease
"We would not be able to say for certain that a patient is reaping the full potential benefits of GLP-1 medications that have been shown in recent clinical trials