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The resulting cysteine is unstable at extracellular level, and it is rapidly autoxidizes to cystine

This effect has been observed in various tissues, like tendons, muscles, and skin

509 Clinical evidence indicates that the expression of ER stress-related proteins such as IRE1, PERK, and CHOP is reduced in SLE patients, while the levels of XBP1 and midbrain astrocyte-derived neurotrophic factor (MANF) are elevated, suggesting their potential role in disease development

The Lancet, 402 (10403), 705-719