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5.3 Gene and epigenetic editing Emerging strategies in the genetic and epigenetic regulation of macrophage polarization, notably the CRISPR-Cas9 system and miRNA-based therapies, offer innovative approaches for precise immunophenotype modulation ( Figure 5 )
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(1999) showed CRH-deficient mice can have normal stress-induced suppression of food intake, implicating other CRH-like molecules
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