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Infusion of GLP-1 into healthy humans and diabetics by several groups established the role of GLP-1 as an incretin and a potential therapeutic for diabetes
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Animal studies spanning over 20 years show gastric ulcer healing, tendon repair, muscle regeneration, and neuroprotection with minimal toxicity, even at doses 10 to 100 times the therapeutic range (Sikiric et al., Curr Pharm Des 2018)
a yearly increasing list of IGFBPs proteases
00:12:22 Vickie Danaher On the other hand, CYP3A4 inhibitors increase orforglipron exposure, which may increase the risk of adverse reactions
Practical approaches include taking stairs instead of elevators, parking farther from destinations, standing while working when possible, and taking brief walking breaks every hour
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