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The reaction between NO and O forms peroxynitrite (ONOO ), a potent RNS capable of nitrating and damaging cellular structures

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Resistance Mechanisms : Unlike normal cells, cancer cells could even evolve to be resistant to therapies designed to affect lipid peroxidation, either by increasing their antioxidant activity or by altering metabolic pathways

10.1016/S2468-2667(18)30135-X Lancet Public Heal

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