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Back Drucker, DJ, Philippe, J, Mojsov, S, et al (May 1987) 'Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line', Proceedings of the National Academy of Sciences , 84/10, 3434-8
Rapid weight loss shifts oestrogen metabolism, and obesity itself independently affects cycle regularity, so several factors can be at play
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A patient with BMI 35 or higher would also meet Tier 1 by BMI alone
Exendin-4 administration reduced visceral hypersensitivity in a dose-dependent manner and decreased serotonin levels in the colon
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