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Overall, interventions with various polyphenolsincluding sesamol, quercetin, Q3G, Triphala, ginger, pterostilbene, curcumin, polymannuronic acid, and CAconsistently elevated key metabolites such as SCFAs, which were associated with improved cognitive function, reduced neuroinflammation, and enhanced gut-brain axis activity in both AD and PD models [32, 33, 36,37,38, 41, 42, 44, 45]

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