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This modification resulted in enhanced ALP-activity, mineralization, and osteogenic marker expression ( ALP , COL1A1 , RUNX2 ) via autocrine signaling

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Tirzepatide (Mounjaro, Zepbound) Tirzepatide targets both GLP-1 and GIP receptors, producing greater average weight loss than semaglutide in head-to-head trials, typically 20 to 25 percent of body weight

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Expression of adipose differentiation genes