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[7] It should not be used in individuals with hormone-sensitive tumors, such as prostate cancer or breast cancer, due to the risk of stimulating tumor growth through increased androgen or estrogen production
Participants saw the largest weight reduction when prescribed the maximum dose of tirzepatide (between 10 and 15 milligrams)
This partial agonism is intrinsic to orforglipron's binding mode: as an allosteric agonist occupying a smaller binding pocket with fewer receptor contacts than peptide ligands, it stabilizes a receptor conformation that is somewhat less efficient at coupling to Gs proteins than the fully peptide-activated state
mean VAT was 176 cm2
