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As mentioned, a secondary analysis of an RCT assessing the cardiometabolic effects of exenatide in 40 people with schizophrenia 140 also looked at measures of cognition and psychosocial functioning (that is, Brief Assessment of Cognition in Schizophrenia, ReyOsterreith Complex Figure Test, Short-Form Health Survey, Personal and Social Performance Scale, Positive and Negative Syndrome Scale), but found no effect for this GLP-1RA compared with placebo over 3 months 133
This variety and the nature of the data means its difficult to determine the recommended doses
Its important to remember that the best results will happen when you are using your medication in combination with a healthy diet and exercise
GLP-1 receptors are expressed in cardiac tissue, kidney tubules, hepatocytes, and neuronal populations, and sema has been used as a research tool to probe the physiological significance of GLP-1R signaling in these organ systems under controlled experimental conditions
5 As hyperglycemia progresses, patients are prone to develop pathological changes such as endothelial dysfunction and thickening of the vascular basement membranekey features of diabetic microangiopathy
