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Summary Cellular senescence, marked by irreversible cell cycle arrest and the secretion of proinflammatory factors, contributes to aging and cancer recurrence

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Furthermore, AQ-QI- and DEAQ-QI-induced cytotoxicity was reduced in GSTP1 -transfected cells under GSH-depleted conditions

Western blot analysis further confirmed that H2O2 treatment led to increased levels of senescence-associated proteins p53, Ser15-phospho-p53, and p21