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Alternative GLP-1 receptor agonists If semaglutide causes significant side effects or concerns about b12 status arise, other GLP-1 medications offer alternatives

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PMID 25327251

NNMT is an enzyme that regulates energy metabolism by methylating nicotinamide, a precursor to NAD+, into 1-methylnicotinamide

Anyone with digestive conditions affecting absorptionincluding Crohns disease, celiac disease, or history of procedures affecting stomach or intestinesneeds the digestive bypass injections provide

For example, 7.5mg could be divided into two 3.75mg injections 3-4 days apart