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[1] [2] This gradual accumulation is one reason why titration decisions are made over several weeks rather than days
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Theoretical or documented interactions include: Immunosuppressants (particularly ciclosporin, where clinical interaction has been documented) Medications metabolised by CYP3A4 or CYP2D6 enzymes Medications that are P-glycoprotein substrates Consult your pharmacist or GP before taking berberine alongside any regular medications, particularly those with a narrow therapeutic window
Managing them alongside other side effects, rather than in isolation, produces better outcomes and less anxiety
But here's the thing they buried it deep
These side effects are generally mild and tend to decrease over time
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