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International Patent Application No

Another embodiment provides a method for reducing stimulant toxicity comprising providing a patient with at least one polar, hydrophilic prodrug of the stimulant of the present technology, wherein the polar hydrophilic moiety can increase the rate of clearance of pharmacologically active stimulant (i.e., released stimulant such as amphetamine) when given at doses exceeding those within the therapeutic range of the stimulant

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Cysteine availability and feedback regulation by GSH can influence the reaction

PeerJ 11:e14765 Mao Q, Zhang H, Zhang Z, Lu Y, Pan J, Guo D, Huang L, Tian H, Ma K (2024) Co-decoction of Lilii bulbus and Radix Rehmannia Recens and its key bioactive ingredient verbascoside inhibit neuroinflammation and intestinal permeability associated with chronic stress-induced depression via the gut microbiota-brain axis

However, with appropriate dose adjustment and consistent use, oral formulations can support meaningful clinical response for many patients