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These effects are often dose-related and may improve over time as the body adjusts
Chronic NSAID use with semaglutide raises the likelihood of developing gastric ulcers or erosions in the stomach lining
Further studies are warranted to evaluate their role in combination regimens alongside other evidence-based therapies
However, it did have a significant facilitative effect on fear extinction (Ozawa et al
Conversely, many celiac patients gain excessive weight after starting a gluten-free diet due to improved absorption and the higher caloric density of many gluten-free products, making tirzepatide potentially beneficial for weight management in this subset, provided they meet the BMI criteria (30 kg/m or 27 kg/m with a weight-related comorbidity)
This new molecule, by acting synergistically on combined systems known to be altered in T2DM [33, 34], could indeed expand the therapeutic potential of GLP-1 agonists/analogues, suggesting new scenarios in terms of improving glycemic control, weight management, and hopefully providing protection against chronic micro-macrovascular complications and not only limited to hepatic complications
