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Researchers who notice uncomfortable heart rate increases should consider reducing caffeine intake, particularly in the first few months of treatment when cardiovascular effects are most pronounced
Niacinamide (vitamin B3) has been added to some compounded tirzepatide formulations as well
In December 2024, a phase IIa dose-ranging trial (NCT06717425 ) to investigate this drug began, and is due to end in December 2025 5
This may help reduce joint pain, muscle fatigue, and improve overall tissue resilience
And if you happen to be one of the 5-10% of users struggling with diarrhea or vomiting on your medication, you'll need to replenish your fluids even more rapidly
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