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5 Conclusions While icodec pharmacokinetics and semaglutide total exposure were unaffected by the combination of icodec and semaglutide in IcoSema, the maximum concentration of semaglutide was higher and occurred earlier presumably owing to icodec outcompeting semaglutide for albumin binding locally at the injection site

[176] Additionally, alcohol may affect immune function and could potentially compound the immunosuppressive effects of corticosteroids

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