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Fatigue Some researchers report tiredness during the first few weeks, particularly during caloric deficit

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However, it has not been proven to reduce appetite or promote weight loss

References 1 LundPKGoodmanRHDeePCHabenerJF

Those interested in berberine should discuss its use with their healthcare provider, particularly if they have diabetes, take other medications, or have cardiovascular disease, as professional guidance can help integrate supplements safely within an overall treatment plan while maintaining appropriate monitoring and medication management

Morning is the most studied window