Side Effects and Precautions Common side effects include: Dry lips and dry skin Peeling or flaking of the face Nosebleeds Headaches Muscle or joint pain Photosensitivity Serious but rare side effects may involve: Elevated cholesterol or liver enzymes Mood changes Vision changes Gastrointestinal symptoms Birth defects (if used during pregnancy) Important precautions: Monthly lab tests (CBC, liver enzymes, cholesterol, triglycerides) are required Women must commit to pregnancy prevention programs (e.g., iPLEDGE in the U.S.) Avoid alcohol, Vitamin A supplements, and tetracycline antibiotics during use Do not donate blood during and for at least 1 month post-treatment Use moisturizer and SPF daily to prevent dryness and sun sensitivity Store capsules in a cool, dry place away from direct sunlight Treatment Duration and Results Patients typically undergo a treatment course of 4 to 6 months depending on dosage and skin response

SNAC Pharmacokinetics SNAC exposure in the fed, fasting and reference groups in the food-effect trial is shown in Supplementary Figs
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