Gastrointestinal side effects are additive and sometimes severe
HOLST: Yeah so again, if I can go a little bit historical here, it was known and suspected that the gut was an important link in the regulation of appetite and food intake
However, GLP-/GIP dual agonists have been proved to be orally effective in animal experiments, and its state in plasma is more stable than GLP-1RA [141], and this oral administration method has gradually been applied to the clinic [142]
The goal is always the lowest effective dose that delivers meaningful outcomes
Presented for research literature review only Hawkes N (2017)
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