Low-impact exercise and physical therapy to encourage circulation and collagen remodeling
In a recent study, administration of exendin-4, a long-acting GLP-1RA, stimulated -cell proliferation in juvenile human islets by inducing gene expressions of calcineurin/nuclear factor of activated T cells (NFAT) signaling, a proliferating factor such as NFATC1, and a cell cycle regulator such as cyclin A1 [57]
The other two strains used in GLPitDIET, namely HY7601 and KY1032, have shown anti-obesity effects by regulating the gut microbiota
This study included 12 week-old Wistar albino male rats that were bred in-house at the animal facility at the Department of Pharmacology, School of Medicine in Zagreb, Croatia
(2024, November 14)
This approach is particularly relevant in 2026, as demand for GLP-1 therapies continues to outpace traditional access models