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At physiological pH, cytochrome c has a net positive charge (+8), establishing an electrostatic bond with the anionic cardiolipin ( c has a hydrophobic channel through which one of the four-acyl chains of cardiolipin inserts
There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision
After 3 months, you'll take a reassessment, and your doctor will adjust your next protocol based on your progress
10.1016/j.clnu.2022.07.040 Clin Nutr
However, results from animal experiments cannot be extrapolated to clinical settings
Corcoran GB, Racz WJ, Smith CV, Mitchell JR: Effects of N-acteylcysteine on acetaminophen covalent binding and hepatic necrosis in mice
