The most frequently reported adverse effects are gastrointestinal: nausea, vomiting, and diarrhea, which in published RCTs often occurred at rates similar to or only modestly above placebo
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M.BgenholmR.ThoresenM
Specifically, histone Kla, especially H3K18la, enhances the transcriptional activity of NFS1 cysteine desulfurase (NFS1), a key player in ironsulfur cluster biosynthesis, thereby reducing the susceptibility of HCC to ferroptosis and promoting metastasis
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