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In 2015, triple agonists simultaneously targeting the GLP-1R, GCGR, and GIPR were also developed, whose weight loss in mice exceeded those of the dual agonists [26]
The most noticeable difference in whole-brain activity signatures between GLP-1MK-801 and semaglutide was the significantly higher number of cFOS + cells in the nucleus accumbens in response to GLP-1MK-801 compared with semaglutide and vehicle treatment
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