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When you combine them, you may get a synergistic effect

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Because citrulline is not metabolised by arginase in the liver and is efficiently converted to arginine in the kidneys, it may raise plasma arginine levels more effectively than arginine supplementation itself

Who Should Not Start This Stack Because CJC-1295 Ipamorelin stimulates growth hormone, patients with active malignancy, a personal history of certain cancers, pregnancy, breastfeeding, uncontrolled diabetes, or significant pituitary disease are generally not candidates

Sermorelin Sermorelin is a growth hormone pathway research compound commonly evaluated in studies focused on GHRH and growth hormone pathway research

Bibcode:2010PNAS..107.6526O