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ALLOSTERIC A term used to describe proteins that have two or more binding sites, in which the occupancy of each site affects the affinities of the others

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Akel A, Wagner CA, Kovacikova J, Kasinathan RS, Kiedaisch V, Koka S, et al

Considering the prolonged half-life of most GLP-1 agonists currently prescribed, it is unfeasible to withhold these agents for weeks prior to surgery to achieve normalisation of gastric function with unknown impact on aspiration rates, appreciating the detrimental effects of poorer glycaemic control on withholding these agents and associated higher risk of peri/postoperative complications (major cardiovascular events, poor wound healing, increased wound infection etc.)

Understanding how retatrutide works at the molecular level is important for patients considering peptide-based therapies

Taking the Next Step Taking the Next Step If youre struggling with weight gain during perimenopause and traditional approaches havent worked, it may be time to explore whether GLP-1 weight loss injections could be part of your solution