10.1016/j.ejphar.2024.176440 21 EspinosaD
A small 2017 clinical trial concludes that glutathione could help treat nonalcoholic fatty liver disease due to its antioxidant properties and potential to detoxify
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Furthermore, if APAP metabolism occurs in the face of limited GSH levels, such as in the case of alcohol consumption, free unconjugated NAPQI reacts with sulfhydryl groups on cysteine and lysine residues, generating NAPQI-protein adducts (APAP-protein adducts) in hepatocytes, particularly in mitochondria, leading to mitochondrial dysfunction and cell death (Yuan and Kaplowitz, 2013)