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Melanotan I and II are greater than 1000 times more potent than your bodys own -MSH because of resistance to enzymatic breakdown

S., Nakaya, N., Abu-Asab, M., Kim, H

sales of ~$4.3B, and recently approved Zepbound (~$1.7B 1H24)

The critical difference is pharmacokinetic profile and the resulting GH secretion pattern

2020 (JCI Insight) Mechanistic follow-up: tesamorelin shifted liver transcriptomic signatures toward oxidative phosphorylation and reduced inflammatory signaling