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For perspective, prior to 2023, the top-selling drugs were largely immunology or oncology biologics (like Humira, Keytruda, Eliquis), but by mid-2024, the list transformed GLP-1 agonists entered the top ranks
Receptor activation raises intracellular cAMP, which triggers calcium influx and GH exocytosis
Hausner H, Derving Karsbol J, Holst AG, et al
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Sci Transl Med 2013;5:209ra151.ArticlePubMed 26
doi: 10.1111/bph.16478 123 KusminskiCMPerez-TilveDMllerTDDiMarchiRDTschpMHScherePE
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