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Traditional weight loss methods rely on: Restriction Willpower Calorie counting Temporary routines Exercise pressure But biology does not simply respond to effort
In the MD Anderson cohort, semaglutide and tirzepatide users had a median weight change of -2.6% at 12 months, smaller than the figures typically seen in general obesity trials
10.1038/s41467-018-05944-5 232 RossnerP.OrhanH.KoppenG.SakaiK.SantellaR
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