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In addition, a meta-analysis suggests it is not the most effective mucolytic agent for COPD (45)

Presented for research literature review only Nimmo IA (1987)

Copper toxicity concerns are generally minimal with topical applications due to limited systemic absorption

K., Kanikarla-Marie, P., Warden, C

Horse gelatin contains negligible amounts of arginine

For GHK-Cu wound healing, this means explicitly communicating: GHK-Cu is not FDA-approved as a drug for any indication Human wound-healing evidence is limited to small, non-randomized studies The compounding pharmacy source is not subject to the same oversight as FDA-approved manufacturers Alternative, evidence-based wound-healing options exist (negative pressure wound therapy, growth factor therapies like becaplermin, advanced wound dressings) Monitoring will be required, with associated lab costs Document this conversation in the medical record