The most common gastrointestinal side effects include: Nausea : Reported in 15-44% of patients (higher rates at Wegovy 2.4 mg), typically most pronounced during dose escalation Diarrhea : Affects approximately 8-30% of users, ranging from mild to moderate severity Vomiting : Occurs in 5-24% of patients (higher rates at Wegovy 2.4 mg), often associated with rapid dose increases Abdominal pain : Experienced by 5-20% of patients, usually described as cramping or discomfort Constipation : Paradoxically affects 3-24% despite the medication's effects on motility Dyspepsia and gastroesophageal reflux : Related to delayed gastric emptying These effects result from semaglutide's pharmacologic action on GLP-1 receptors throughout the gastrointestinal tract
Dissolution: Swirl gently in a smooth circular motion
Endocrinology 154 , 127139 (2013)
very timely I love the energy it gives me but I havent lost a single pound Feeling and starting to see results So far so good
Hack V, Schmid D, Breitkreutz R, et al
Valenzuela-Vallejo L, Guatibonza-Garcia V, Mantzoros CS