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Hypersensitivity reactions occur at low rates
Common Side Effects, Monitoring Protocols & How to Manage Them It has been prescribed for decades, and its side-effect profile is well established
Moreover, no clinically significant impact was detected even in cases of a decrease in the AUC
In the left panel, I'm depicting omeprazole partially failing to treat patients' GERD because not all of its granules can pass through the stomach and into the small intestine, where it's absorbed (even with its enteric-coated granules protecting the unstable molecule in an acidic environment)
doi: 10.1038/s41586-019-1785-z 29 Henao-MejiaJ.ElinavE.JinC.HaoL.MehalW
However, with increased efficacy can come higher rates of gastrointestinal side effects, which should be discussed extensively between patient and provider
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