Here is what the evidence shows
The most common is slight redness, swelling, or tenderness at the injection site, which usually resolves quickly
Semaglutide injections are self-administered once weekly as an injection under the skin, and semaglutide pills are taken once daily
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Although it has been in clinical use for decades, its mechanism of action is still under investigation
A 2026 evidence review of microglial synaptic pruning, HGF/c-Met signalling, neuroinflammation, NHS treatment gaps, and realistic expectations for the UK's 2.1 Read the full review Autoimmune, Gut & Inflammatory Where immune activity and the gut meet cognition