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Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments

It was reclassified from FDA Category 2 (restricted) back to Category 1 (compoundable) following HHS Secretary RFK Jr.s announcement on February 27, 2026

The lysine residue's positive charge facilitates interaction with glycosaminoglycans and negatively charged phospholipids in cellular membranes, enhancing uptake efficiency

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