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Real-world results for blockbuster weight-loss meds like Ozempic, Wegovy and Zepbound aren't as impressive as those promised by the drugs' clinical trials, a new study says

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Although the overall incidence is estimated at 1/5000 to 1/50,000, the occurrence of fatal hepatotoxicity could be as high as 1/800 to 1/500 in these high-risk groups [11]

Obesity in and of itself is a legitimate, serious chronic disease, but people often confuse the accumulation of excess adipose tissue as a disease

For the prescriber, this is the clinical rationale for fixed-dose combination therapy over monotherapy