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Interestingly, when growing in proline medium, in which the gdh3/gdh3 mutant cells failed to undergo morphogenesis, they exhibited an overall reduction in extracellular metabolite levels when compared to the wild-type, with the exception of nicotinate, malate, and succinate levels

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In this regard, systematic reviews suggest that oral collagen can contribute to reducing or delaying skin aging [82,83,84] and expanding its applications to meet the evolving dermatological challenges [85]

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