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GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and the dual GIP/GLP-1 agonist tirzepatide provide the mechanism and the trial record, including STEP (NEJM 2021), SURMOUNT (NEJM 2022), and SURMOUNT-OSA (NEJM 2024)
Federal regulators have approved the GLP-1 tablet Foundayo for use in weight management
Therefore, the package labeling for semaglutide advises that both men and women who are planning a pregnancy discontinue the medication for **two months** before trying for a pregnancy
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Urine homocysteine measurement is not useful as renal excretion does not seem to be an important route of elimination
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