GIP receptors are also expressed in the brain, and their activation may contribute to mood stabilization in ways that pure GLP-1 agonists do not achieve
That being said, vigilance is warranted particularly in patients with biliary disease, prior pancreatitis, or rapid recent weight loss
While the manufacturers of Mounjaro claim GIP "may complement the effects of GLP-1 receptor agonists," there are limited studies examining the benefits and efficacy of combining the two synthetic incretin hormones
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Gadag S, Narayan R, Nayak AS, Catalina Ardila D, Sant S, Nayak Y, et al