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was supported by a Gates- and DTP-MR PhD studentship
doi: 10.1155/2015/848595 172 ShigetomiHImanakaSKobayashiH
CHAC1 exacerbates arsenite cytotoxicity by lowering intracellular glutathione levels
The PepT1 transporter adds another dimension: KPV's anti-inflammatory mechanism is delivered directly into inflamed gut cells via a transporter that is selectively upregulated in diseased tissue
From a biological perspective, ferroptosis is characterized by elevated ROS levels, iron accumulation, mitogen-activated protein kinase (MAPK) activation, decreased cysteine uptake, and glutathione (GSH) depletion [108, 109]
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