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A series of pyrimidine derivatives exemplified by 2 emerged from these hits (Fig

1 Introduction Myocardial infarction (MI) remains a significant contributor to morbidity, but mortality has been significantly reduced in the last decades due to the introduction of thrombolytic therapy and acute vascular interventions ( In contrast to the limited self-repair capacity of the adult heart, the heart of newly born mice has a strong regenerative capacity, and the proliferation of the newly formed cardiac tissue comes mainly from the proliferation of endogenous cardiomyocytes ( In recent years, researchers have found that the mammalian heart converts its major metabolic substrate from glucose to fatty acids shortly after birth

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However, the cause of the dopamine surge potentially affecting neuronal health has remained elusive