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Hu MI, Waguespack SG, Dosiou C, Ladenson PW, Livhits MJ, Wirth LJ, Sadow PM, Krane JF, Stack BC, Zafereo ME , Ali SZ, Weitzman SP, Hao Y, Babiarz JE, Kennedy GC, Kloos RT

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( a , b ) Cumulative distribution plot of observed percentage change from baseline over time in body weight for participants in the full analysis set during the in-trial observation period* (a) and on-treatment observation period (b)

This triple mechanism distinguishes it from existing approved treatments such as semaglutide (which targets GLP-1 alone) or tirzepatide (which targets GLP-1 and GIP)

The company had set an internal ambition of 25% or greater weight loss, a threshold REDEFINE 1 did not reach