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Triple agonists: Retatrutide (GIP/GLP-1/glucagon)

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Patients not on treatment or on other antihyperglycemic agents entered a run-in treatment period of up to 12 weeks duration with metformin HCl immediate-release monotherapy (dose of 1500 mg per day) which included washout of medications other than metformin immediaterelease, if applicable

The fatty acid acylation of cagrilintide enables albumin binding in circulation, reducing renal clearance and extending the elimination half-life to support once-weekly dosing

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When in this state, the body turns to its stored reserves for energy