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They enhance autophagy and reduce lipotoxicity-induced hepatocyte apoptosis, thereby preserving the integrity of liver parenchyma ( action to enhance anti-fibrotic efficacy ( In summary, GLP-1 receptor agonists exert anti-fibrotic effects in MASLD through the inhibition of hepatic stellate cell activation, the modulation of profibrotic signaling pathways, and the promotion of hepatocyte regeneration

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Pharmacokinetic drug interaction studies with Janumet have not been performed

References Sikiric P, Seiwerth S, Rucman R, et al