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doi:10.1128/jb.179.5.1431-1441.1997
Selenium also activates transcription factors TFAP2c and Sp1 to further enhance the activity of GPX4 and protects neurocytes (129)
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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]
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