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With the pheomelanin synthesis promoted by Glutathione, the intracellular melanogenic enzymes are inhibited, and it has anti-aging and antioxidative effects on the skin

Cagrilintide was developed to restore and enhance these amylinomimetic effects with a more convenient dosing schedule than pramlintide (the first-generation amylin analog requiring multiple daily injections)

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The combined tirzepatide groups exhibited a more favorable decline in estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) compared to the insulin glargine group