PLoS One 6:e21827
Phase one is 9%, phase two is 12%, phase three is 29% with the rest of it coming from that early basic research, drug discovery, preclinical studies, and a little bit later with the regulatory review
A dysfunctional OCTN2 transporter reduces this gradient because of a compromised myocardial carnitine transport as well as a result of low plasma carnitine concentration subsequent to excessive renal loss of carnitine
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2021 Feb 10
M., Begum, S., Shi, C., Eshleman, J