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Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Read LC, Ballard FJ
Clinical trials show that some users lost 15% or more of their body weight
In the Lira Pump study, they decreased basal insulin by 10%, but increased bolus by 15% ( Our current practice is to consider a ~20% bolus insulin decrease and a ~10% basal insulin decrease before GLP-1RA initiation, although prior A1c, risk of hypoglycemia, potential risk of ketosis due to reduced insulin doses, as well as other patient-specific factors should guide the final insulin dose changes
In this group, 963 participants using GLP-1RAs developed depression, and 1,075 participants using DPP4is developed depression
What to Do If You're Concerned If any contraindications apply to you, tell your doctor right awaythey can suggest other options like lifestyle changes or different meds
Koole, C., Savage, E
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