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Funding This research was funded by the Spanish Government through Instituto de Salud Carlos III (PI22/01899)

Remaining TR activity as a function of inhibitor concentration is plotted for a

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Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions

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Although ROS production correlates with bile acid concentration, clinically significant injury remains largely idiosyncratic and amplified in genetically susceptible individuals (e.g., SLCO1B1 variants)