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A number of randomized controlled trials (RCTs) [33] [52] - [57] , systematic reviews, and metanalyses of melatonin use in NDDs, particularly ASD, both following or alongside behavioural interventions [17] [40] [51] [58] - [60] have consistently found that melatonin reduces time of sleep onset
Instead, they function by inhibiting the activity of peripheral DOPA decarboxylase (DDC), which reduces the conversion of levodopa in peripheral tissues and increases its availability in the central nervous system, while also minimizing side effects such as nausea and vomiting (Gremke et al., 2022)
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J Clin Endocrinol Metab 1995
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Antioxidant Effect of a Dietary Supplement Containing Fermentative S-Acetyl-Glutathione and Silybin in Dogs with Liver Disease
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